Melatonin and Migraine Headaches
Ask the Scientists – Health and Science Education
The role of melatonin is not limited only to sleep. No single therapy works for everybody, but here is some very recent research to consider if you suffer from migraine headaches.
Randomized clinical trial comparing melatonin 3 mg, amitriptyline 25 mg and placebo for migraine prevention
A recently published clinical trial shows that taking melatonin (3 mg) at bedtime for 12 weeks is as effective for migraine prevention as a commonly used medication called amitriptyline (25 mg). The trial compared the use of melatonin, amitriptyline and placebo once daily in people with 2-8 migraine attacks monthly. Melatonin reduced headache days by 2.7 compared to 2.2 days for those receiving amitriptyline. In addition, melatonin cut migraine frequency in half for more patients than those taking amitriptyline. Melatonin was as well tolerated as placebo and resulted in fewer side effects than amitriptyline.
“Melatonin 3 mg is effective and better than placebo for migraine prevention. Melatonin is as effective as amitriptyline 25 mg in the primary end point, but better than amitriptyline in the secondary end point (50% responder rate, patients with a higher than 50% improvement in headache frequency). It is more tolerable than amitriptyline 25 mg.”
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